Chlorothiazide should be used cautiously in patients with renal disease resulting in severe renal impairment because the drug decreases the glomerular. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Diuril (Chlorothiazide). Chlorothiazide sodium for injection, USP is a diuretic and a vial containing: Chlorothiazide sodium equiva- . toxicity. Refer to the package insert for lithium.

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Moderate Risperidone may induce orthostatic hypotension and thus enhance the hypotensive effects of antihypertensive agents. Periodic evaluation of blood pressure is advisable during concurrent use of methylphenidate and antihypertensive agents, particularly during initial coadministration and after dosage increases of methylphenidate.

Hypomagnesemia occurs with thiazide diuretics chlorothiazide, hydrochlorothiazide, indapamide, and metolazone. In addition, packave may cause fluid and electrolyte imbalances and may precipitate or exacerbate urinary incontinence.

Discontinuation of the SNRI should be considered in patients who develop symptomatic hyponatremia. Patients receiving hawthorn concurrently with antihypertensive medications should receive periodic blood pressure monitoring. Moderate Methylphenidate can reduce the hypotensive effect of antihypertensive agents such as thiazide diuretics. Careful monitoring of blood pressure and hypotensive symptoms is recommended especially in patients with ischemic heart disease and in patients on antihypertensive agents.

Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals. Since thiazides reduce the clearance of uric acid, patients with gout or hyperuricemia may have exacerbations of their disease.

Discard unused portion – Store unreconstituted product at 68 to 77 degrees F Sodium Diuril: Intravenous use of chlorothiazide in infants and children has been limited and is not generally recommended; however, dose recommendations for IV chlorothiazide are available based on extrapolation from oral absorption data. Moderate Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents.


Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide sodium. Moderate High doses of fish oil supplements may produce a blood pressure lowering effect.

Cosyntropin may accentuate the electrolyte loss associated with diuretic therapy. Hypercalcemia may be exacerbated by coadministration of vitamin D or vitamin D analogs and thiazide diuretics. Related Drug Information Drug Summary. Moderate Concurrent administration of antihypertensive agents could lead to additive hypotension when administered with milrinone.

The risk of QT prolongation may also be increased during use of haloperidol and medications known to cause electrolyte imbalance such as thiazide diuretics. Thiazides diuretics usually do not affect normal blood pressure. Use caution when coadministering amiodarone with drugs which may induce hypokalemia and, or hypomagnesemia including thiazide diuretics. This additive effect may be desirable, but dosages must be adjusted accordingly.

When concurrent therapy with a thiazide diuretic and carbamazepine is necessary, monitor patients for hyponatremia.

Akorn – Sodium DiurilĀ® (chlorothiazide sodium)

Patients who can not stop their antihypertensive agents should not receive amifostine or be closely monitored during the infusion and, possibly, given lower doses. Extravasation must be strictly avoided during IV administration of chlorothiazide to prevent tissue necrosis. This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. Monitor more frequently in patients with a history of hypercalcemia.

Electrolyte imbalances may occur while on these diuretics, which may in turn predispose patients to the cardiac effects of halofantrine. Reserve IV chlorothiazide for patients unable to take oral medication or for emergency situations. Caution is advisable inserg patients receiving medications known to cause hyponatremia, such as diuretics.

Minor Coadminisitration of thiazides and prokinetic agents may result in decreased bioavailability of the thiazide diuretic.

If an NSAID and a diuretic are used concurrently, carefully monitor the patient for signs and symptoms of decreased renal function and diuretic efficacy. Safety and efficacy have not been established for IV formulation. Moderate Although to a lesser extent than cholestyramine, colestipol also has been shown to inhibit the GI absorption and therapeutic response of thiazide diuretics. Information on oral dosing in this age group is supported by evidence from empiric use in pediatric patients and published literature regarding the treatment of hypertension in such patients.


There are many drug interactions that can potentiate the effects of antihypertensives. There are no well-controlled clinical trials of chlorothiazide in children. Hypokalemia may develop especially with brisk diuresis, when severe cirrhosis is present or after prolonged therapy.

Prevention of photosensitivity includes adequate protection from sources of UV radiation e. Extravasation must be strictly avoided. When chronically administered, diuretics decrease peripheral vascular resistance. Extravasation, intramuscular administration, subcutaneous administration. Therefore, clinicians should monitor serum magnesium concentrations periodically in patients taking a PPI and diuretics concomitantly.

Periodic evaluation of blood pressure is advisable during concurrent use of dexmethylphenidate and antihypertensive agents, particularly during initial coadministration and after dosage increases of dexmethylphenidate. If progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy.

The potential reduction in blood pressure can precipitate orthostatic hypotension and associated dizziness, tachycardia, and syncope. Use the smallest dosage necessary to achieve the required response. Marked hypercalcemia may be evidence of hidden hyperparathyroidism. Serum electrolytes and creatinine should be assessed prior to administration of cisapride and whenever conditions develop that may affect electrolyte imbalance or renal function.

Major Patients receiving antihypertensive agents should be closely monitored during amifostine infusions due to additive effects. Dosages should be adjusted carefully, according to blood pressure.

Moderate Electrolyte disturbances e.